One Shot Fat Keto Diet: As a disclaimer, it is important to realize that the long-term effects of being on a ketogenic diet are not yet understood. Some doctors are concerned that a ketogenic diet may place stress on the kidneys, putting one at greater risk of kidney stones due to excess urination of ketone bodies. The long term effects of ketosis on the liver, where the biochemical process of ketosis takes place, is also unknown. Scientists and doctors are currently unsure of the correlation between ketosis and the reduction of seizures. One hypothesis is that the brain prefers ketone bodies as a source of fuel over glucose. suggests that a ketone metabolism prevents glutamate from producing an overabundance of aspartate in favor of, an inhibitory neurotransmitter .